off the top of my head
Duane - Dreams, Goin Down Slow
Dickey - Stormy Monday
Derek - Midnight in Harlem
David Gilmour - Comfortably Numb
Jerry Garcia - Morning Dew
Charlie Parker - Parker's Mood, Bird of Paradise
Trane - Nature Boy, Liberia
Miles - So What

[Edited on 11/5/2015 by stormyrider]

Mick Taylor, Rolling Stones, "Time Waits for No One," "Shine A Light"

Steve Hackett, Genesis, "The Carpet Crawlers," "The Lamia"

Guthrie Govan, The Steven Wilson band, "Drive Home"

Jimmy Page, "Ten Years Gone," "The Rover"

Tommy Bolin, "Savannah Woman"

Ritchie Blackmore, "Wasted Sunsets" (Deep Purple), "Weiss Heim" and "May b e Next Time" (Rainbow)

[Edited on 11/5/2015 by JimSheridan]

Steely Dan- Reeling In The Years (Both solos)

both guitar solos little martha/ blue sky 3/23/2009 Beacon

I still go nuts over :

Blue Sky - EAP
Mountain Jam 2nd half - EAP

Mick Taylor, Rolling Stones, "Time Waits for No One," "Shine A Light"

[Edited on 11/5/2015 by JimSheridan]

+1 on both accounts.

I still go nuts over :

Blue Sky - EAP
Mountain Jam 2nd half - EAP

yes
Duane's slide on MJ is perhaps my favorite officially recorded music ever

Alex Lifeson- La Villa Strangiato
Jimmy Page- Since I've Been Loving You (MSG)

I still go nuts over :

Blue Sky - EAP
Mountain Jam 2nd half - EAP

yes
Duane's slide on MJ is perhaps my favorite officially recorded music ever

Yep Mtn jam PT 2 is some of the most beautiful music I've heard.....Top on my list....the places Duane takes that section just blows me away....I can hear the whole solo in my head....it's implanted into me at this point

Studio Dreams....Blues Sky

Jerry's Solo from Skull & Roses during both Not fade away the jam and GDTRFB

Duane E Reed LFE

The Piano solos from Chuck on Jessica BS - high falls WLOD and E Reed from WTWCTOADG

[Edited on 11/5/2015 by goldtop]

In addition to many of the songs previously mentioned, this has been one of my all-time favorites since I first heard it back when the album was released...

Frank Zappa - Watermelon In Easter Hay

Can't go wrong with any of the aforementioned solos, but surprised no one has listed Jeff Beck Cause We've Ended as Lovers, Jimi's Little Wing or Wind Cries Mary, or possibly my all time favorite, Robin Trower's Daydream off the live album.

Larry Carlton - Kid Charlemagne
Duane Allman - Beat it on down the line
Wishbone Ash- Blowin' Free
Eric Clapton - Crossroads
Mick Taylor - Can't you hear me knockin'

The Knack - My Sharona!!!

Brother Duane's slide solo on the extended Statesboro Blues on Live at Ludlow Garage in Cincy, April 1970. It's mellow but awesome! also Carlos Santana's solo on Now That You Know from off his CD, BLUES FOR SALVADOR.
AND WHOEVER MENTIONED BRO. DUANES SOLO IN Mt. Jam on EAP. Ditto !!! That one is fantastic. Have a great day brothers and sisters, peace.

Jimi's Little Wing or Wind Cries Mary

yep , and Dickey and Duane on Dreams

Lots of great soloes mentioned here. But the MOST BEAUTIFUL SOLO has got to be Duane at the end of Layla. It's so beautiful it can make me cry

Duane: soul serenade; blue sky; one way out EAP and hot Lanta LAFE (beautiful in his use of tone and sustain even if not a "beautiful" narrative); Please Be Withe Me withCowboy; little Martha; dreams from first album and SF 71 both nights

Duane and Dickey's interplay and harmonies on the intro to EAP my jam; all of My Jam too.

Santana: samba pa ti; lots of Carlos's melodies

Jerry Garcia: eyes of the world from the G D movie

Dickey Betts: waiting for a train from Bob Dylan's jimmy Rogers tribute; blue sky EAP; nobody knows From Set I; one way out EAP (I think this is one of the definitive guitar solos in rock music period. Flawless); Bougainville

Warren Haynes: Captured from Lockin' 2013 (you need to get the soundboard/mule track of this. NEED to)

SRV: Riveara Patadise - live version (this is the version from a mixed artist live bootleg album that Carlos Santana released. Very, very good)

listen to just about this whole medley. Used to say if a woman wouldn't undress to this while dancing it was a lost cause

First one that comes to mind is Clarence Clemons on Jungleland

.... And THIS:

Wes Montgomery In Your Own Sweet Way from The Incredible Jazz of Wes Montgomery.
This is as good as it gets. Ever.

FZ's solo on Inca Roads from One Size Fits All.

And the previously mentioned Watermelon In Easter Hay. It may be Franks finest work.

In addition to many of the songs previously mentioned, this has been one of my all-time favorites since I first heard it back when the album was released...

Frank Zappa - Watermelon In Easter Hay

This is the first thing I thought of (as well as "Inca Roads" and "Black Napkins"). I also dig all of Robben Ford's "Life Song: Song for Annie." Talk about beautiful. I also think Larry Carlton's "For Love Alone" is pretty gorgeous.

"Riviera Paradise" was a good call as well.

Cool thread.

Blooby

Dickey Betts - High Falls

Toy Caldwell - This Ol' Cowboy

Pat Metheny - Last Train Home

Sweet Jane (Dick Wagner and Steve Hunter on guitars on the Rock and Roll Animal verison)
Mark Knopfler - guitar on Going Home, Romeo and Juliet
Michael Breckers sax solo on Your Latest Trick
Santana - Europa (and many others ... some already listed like Samba Pa Ti)
Neil Young - Cortez the Killer (Warrens version of this...)
Duane Allman on Loan Me a Dime
Alvin Lee and George Harrison - Bluest Blues
Jimi was mentioned but I like Eric Claptons version of Little Wing, also,
and While My Guitar Gently Weeps and Can't Find My Way Home (and YES to Old Love)
Mike McCready's guitar solo on Yellow Ledbetter
Toots Thielemans - Bluesette (guitar and whistling and later in life harmonica)
David Lindleys fiddle on For A Dancer and Before the Deluge (David Lindley playing whatever on anything)
Mick Taylor (guitar) and Bobby Keys (sax) on Can't You Hear Me Knocking
Chick Corea (piano) and Gary Burton (vibes) on their cover of Waltz for Debby
Already mentioned but I've got to mention these guitars again -
Mick Taylor on Time Waits for No One and David Gilmour on Comfortably Numb
and of course... Layla

[Edited on 11/6/2015 by lolasdeb]

Mark Knopfler's one two punch on Making Movies- Tunnel of Love & Romeo and Juliet.
Another vote for SRV's Riveara Paradise & also Lenny.
As previously mentioned Dickey's solo on IMOER off Wipe the Windows etc ...
And another vote for Duane's closing slide work on Mountain Jam from Eat a Peach.
Jimi's Wind Cries Mary.

All transspendent! 😉

Sweet Jane (Dick Wagner and Steve Hunter on guitars on the Rock and Roll Animal verison)
David Lindleys fiddle on For A Dancer and Before the Deluge (David Lindley playing whatever on anything)
Mick Taylor (guitar) and Bobby Keys (sax) on Can't You Hear Me Knocking

Alex Lifeson - Xanadu on Exit...Stage Left
Joe Walsh & Don Felder - Hotel California (I know how many people hate the Eagles, have no problem with that :D)
Jimmy Page - Since I've Been Loving You
Jerry Garcia & Bob Weir - The entire performance of Here Comes Sunshine from 12/6/73, also my single most favorite piece of GD music of them all

i really miss the stupendous drum solos of the big rock era. cant think one in particular, im sure Keith
moon topped the bill when I saw the Who in 1974, but i cant recall other than my right ear dont work so good these days.

Wilco - Impossible Germany is great............